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- $Unique_ID{BRK00017}
- $Pretitle{}
- $Title{What is Globulin?}
- $Subject{globulin immune antibody Infections Infection Globulins antibodies
- immune system polio measles hepatitis blood donation plasma rabies tetanus
- diphtheria animal serum intravenous IV deficiencies autoimmune disorder
- disorders thrombocytopenia myasthenia gravis systemic lupus erythematosus}
- $Volume{A-7,U-7}
- $Log{
- }
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- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
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- What is Globulin?
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- QUESTION: What is globulin that doctors give to prevent infection?
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- ANSWER: Globulins are proteins found in the blood stream that contain the
- antibodies the immune system uses to fight disease. Immune globulins are not
- a recent discovery. They have been studied since the early 1900's, and have
- been used to prevent the spread of polio, measles, and hepatitis A. Those
- immune globulins were simply a by-product of blood donation, since they are
- taken from the plasma of several human donors, concentrated and purified and
- contain any antibodies to diseases those donors were exposed to. Specific
- immune globulins with high antibody concentrations to certain diseases, such
- as rabies, hepatitis B, tetanus, and others, are also widely used. For some
- diseases, diphtheria for one, the immune globulins used come from animal
- serum.
- Immune globulins were great breakthroughs in fighting diseases, but they
- have some drawbacks. They had to be injected into a muscle, which is painful
- and which limits the amount that can be administered, making multiple
- injections sometimes necessary.
- An intravenous (IV) form of immune globulin has been created that has
- several advantages over the intramuscular kind. It can be given more
- frequently and in higher amounts, but has the drawbacks of higher cost, the
- need for an IV hookup, and a greater risk of side effects.
- The chief use for IV immune globulin is in helping people who have
- antibody deficiencies and it is also used in treating autoimmune disorders.
- Antibody deficiencies are usually inherited deficiencies of the immune system,
- but some immune deficiencies are secondary to other diseases. People with
- these immune problems are open to almost any infection and immune globulin
- gives them the protections they lack.
- The most famous immune deficiency is AIDS (it's called acquired immune
- deficiency syndrome because it comes from a virus infection and is not
- inherited). Immune globulin gives some protection to children with AIDS,
- those who contracted it from their mothers during birth, but it does not
- appear to help adult AIDS sufferers.
- In autoimmune diseases, where the body is attacking itself, IV immune
- globulin appears to inhibit some of the body's antibodies. It has been used
- to treat a blood condition called thrombocytopenia and has also been tested
- with other autoimmune diseases such as myasthenia gravis and systemic lupus
- erythematosus.
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- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
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